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41 Sorafenib has been recognized as an inducer of ferroptosis, which blocks cystine uptake by inhibiting system Xc- activity, reduces GSH biosynthesis, and thus induces ferroptosis and promotes oxidative stress to induce ferroptosis by increasing mitochondrial ROS production

Nicotinamide adenine dinucleotide plus hydrogen (NADH) produced during glycolysis (anaerobic glucose metabolism in the cytosol) and the citric acid cycle (in mitochondria) donates electrons to initiate the electron transport chain via NADH dehydrogenase

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Weight loss Diet (Mediterranean diet, low-sodium diet) Exercise Alcohol avoidance Side sleeping or at least turning the head to the side while sleeping on your back Acupuncture Smoking cessation What Integrative Interventions May Be Beneficial for Sleep Apnea