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He X, Wu X, Chen R, Chen C, Liu X, Wu B, Huang Z (2016) Effectiveness of omega-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials

5 A), indicating that these cells are undergoing a complex reactive transformation, characterized by ECM remodeling (MMP2, PCOLCE, LAMC2, ADAMTS19, ASPN, OGN, MFAP4, ANGPT2 and collagens COL6A3, COL12A1, COL28A1, COL2A1), cell adhesion, migration and astrocyte-ECM interactions (LOXL2, LAMC2), altered synaptic support and plasticity (WNT7A, LRRTM1, RELN, AGRN), neuroinflammatory signaling (TRIL), reduced regenerative capacity (GDF10, FGFR2) and decreased support to neuron integrity and survival (NDNF, COL2A1 and GDF10)

Increased COX2 expression and decreased GPX4 expression have been detected by western blotting, accompanied by mitochondrial structure changes 337

Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR- 246 in refractory hematologic malignancies and prostate cancer

In: Nordberg GF, Fowler BA, Nordberg M, Friberg LT (eds) Handbook on the toxicology of metals, 3rd edn