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27 Because Fer-1 was more potent than lipophilic or soluble antioxidants, it was hypothesized that its aromatic amine structure may confer a unique profile of radical reactivity upon Fer-1 that is better tuned to the RSL mechanism

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158 Exercise-induced NO in endothelial cells will diffuse into vascular smooth muscle cells, where it activates soluble guanylyl cyclase (sGC) to induce catalytic conversion of GTP to cyclic guanosine monophosphate (cGMP)

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These mechanisms collectively drive inflammatory responses, cellular damage, tissue fibrosis, and progressive organ dysfunction in diabetic complications