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N Engl J Med (2020) 382(18):170820

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and the reduction of leukocyte adhesion ( Betaine is a methyl derivative of glycine that is primarily obtained from dietary sources but is also endogenously synthesized in the liver from choline ( Betaine is stored in the kidney and liver, and serves three important physiological functions: it acts as an osmolyte that regulates cell volume, it acts as a chemical chaperone that protects against protein degradation, and it serves as a methyl donor in the methionine cycle which detoxifies homocysteine to methioninea process that is crucial for numerous cellular functions ( Although homocysteine is commonly associated with cardiovascular diseases, there is increasing evidence supporting its strong correlation with CKD and renal injury (Shih et al., 2022

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Serious whiskey drinkers insist that it tastes better diluted with a little water and, with the help of computer simulations, scientists now know why