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After APAP injection, Ppara fl/fl mice showed gradually elevated serum ALT and AST levels as well as extensive liver necrosis, peaking at 9 hours, and then declined progressively but remained at much higher levels at 24 hours after APAP injection (Fig

(112) showed that a scheduled feeding paradigm was sufficient to reduce mutant huntingtin levels in YAC128 mice expressing cleavable mutant huntingtin