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Combining cystine deprivation with anti-PD-L1 treatment could synergistically promote CD8 + T cell infiltration and establish a positive feedback loop to amplify antitumor immunity

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It is primarily associated with side effects such as nausea, increased heart rate, hyperhidrosis, constipation, urinary hesitation, sexual dysfunction, and potential increases in blood pressure (Asnis and Henderson 2015)