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The study introduces a novel nanomedicine, MgC@PS, that delivers magnesium ions directly to macrophages to inhibit NLRP3 inflammasome activation

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At 5-15 mg/mL concentration, even the highest documented weekly doses (15 mg tirzepatide, 12 mg retatrutide) draw under 1 mL

A standard weight-management titration reference (based on FDA-approved Wegovy protocol): Weeks 14: 0.25 mg once weekly Weeks 58: 0.5 mg once weekly Weeks 912: 1.0 mg once weekly Weeks 1316: 1.7 mg once weekly Week 17 onward: 2.4 mg once weekly (maintenance for obesity) For T2DM glycemic control, lower maintenance doses (0.52.0 mg weekly) are used per Ozempic labeling

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