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The Nrf2 attacks these metabolic enzymes and regulates redox homeostasis by detoxifying ROS and repairing oxidative damage

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Notably, translation- and protein control-related molecules seem to differ in RBCs from different pathophysiological backgrounds, such as with glucose-6-phosphate dehydrogenase deficiency (Tzounakas et al., 2022b), beta-thalassemia trait (Anastasiadi et al., 2021b), and hereditary xerocytosis (Caulier et al., 2022), adding complexity to these simple cells

Local Institutional Ethics Committee at each center approved the study and all patients or their parents signed the informed consent

In infancy and early childhood, melanin in the iris can increase, which is why many babies are born with lighter eyes that darken over the first years of life