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Tirzepatide titration: 2.5mg to 15mg Tirzepatide uses a six-step titration over approximately 20-24 weeks: Weeks 1-4: 2.5mg weekly Weeks 5-8: 5mg weekly Weeks 9-12: 7.5mg weekly Weeks 13-16: 10mg weekly Weeks 17-20: 12.5mg weekly Week 21 onward: 15mg weekly (maximum dose) Not everyone reaches 15mg

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Int J Mol Med 36(5):13691376 Yang S, Zhang X, Zhang H, Lin X, Chen X, Zhang Y et al (2021) Dimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway

doi: 10.5606/tftrd.2022.9741

10.1016/j.mad.2006.11.016 Mech Ageing Dev