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Nagata, C

doi: 10.1016/j.oret.2019.02.002 277 YuL.ChibnikL

Moutzouri, A.G

Recent intervention strategies targeting metabolic symbiosis nodes, specifically a low-leucine diet combined with YAP inhibitors, can effectively disrupt the TI-Treg OXPHOS-immunosuppression axis by inhibiting the YAP-Lars2-leucine pathway, suggesting novel approaches to overcome tumor microenvironment-mediated immunosuppression and therapeutic resistance