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Niebler M, Qian X, Hfler D, Kogosov V, Kaewprag J, Kaufmann AM, et al

87,88 Methotrexate has demonstrated no superiority to placebo in inducing or maintaining remission in UC in a RCT

2008 Dec;14(10):1291-8

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LPS binds to Toll-like receptor 4 (TLR4) on the surface of Kupffer cells, activating both the MyD88-dependent pathway, which mediates NF-B signaling, and the MyD88-independent pathway involving interferon regulatory factor 3 (IRF3), ultimately upregulating TNF- transcription [49, 50]