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Conclusion In conclusion, the present study demonstrates that children with ASD exhibit distinct but subtle plasma metabolomic features , particularly involving branched-chain amino acid metabolism, methyl-donor pathways, and diet-responsive bioactive compounds

Phase 2 results (48 weeks): 1mg dose: 8.7% average weight loss 4mg dose: 17.1% average weight loss 8mg dose: 22.8% average weight loss 12mg dose: 24.2% average weight loss Placebo: 2.1% average weight loss These numbers came from a 48-week study period, six months shorter than the 72-week SURMOUNT trials

The STEP 1 trial demonstrated a mean body weight reduction of 14.9% at this dose after 68 weeks, with 86.4% of participants achieving at least 5% weight loss and 69 to 79% achieving 10% or more

Toxicol Rep 8:376385