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As such, the circulating and metastatic cancer cells upregulate the PGC-1 to facilitate oxygen consumption rate oxidative phosphorylation, and mitochondrial biogenesis to uphold metastasis (137)

One of the things I know people are most fearful about, and it's a reason people choose not to take medication, is osteonecrosis of the jaw, which is rare, but it's this terrible side effect where you have necrotic or dead bone tissue and it makes, for example, the dentists very reluctant to take care of someone who's on one of the bisphosphonate medicines, although, you know, it also happens with some of the other medications

doi: 10.1172/JCI29189 127 KahnSEHullRLUtzschneiderKM

Mitochondrial dysfunction and heart disease: critical appraisal of an overlooked association