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in PDAC, GOT1 and ME1 maintain the NADPH/NADP + ratio via the malate-aspartate shuttle by maintaining GSH levels 56

A British Medical Journal found that when injected into the face, potential side effects of glutathione include toxicity of the nervous system, kidney and liver, plus headaches and rare but serious skin conditions such as Stevens-Johnson syndrome (SJS), a rare, serious disorder of the skin and mucous membranes.

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Popovich DG, Tiaras F, Yeo CR, Zhang W