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Ginsenoside Rg3 prolongs survival of the orthotopic hepatocellular carcinoma model by inducing apoptosis and inhibiting angiogenesis

This activation of Parkin leads to the ubiquitination and labeling of mitochondria, making them for packaging into autophagosomes and subsequent degradation [69]

These modifications can change the structure of protein and produce new epitopes, which may not be covered by central tolerance, so they can trigger immune response under certain conditions

doi: 10.3390/biomedicines10061446 193 TsujiO.MiuraK.OkadaY.FujiyoshiK.MukainoM.NagoshiN.et al