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10.1016/j.jbspin.2022.105521 33 BrindhaT.RathinamR.DheenadhayalanS

A number of cellular stress factors, including hypoxia, nutrient deprivation, and ROS, are important stimuli of angiogenic signaling [220]

Unlike PRP, which relies on naturally occurring growth factors obtained from blood, GHK-Cu is a naturally occurring peptide complex that interacts with biological signalling pathways

Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmerman C, Stevant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jarzelska J, Faivre L, Wilheim D, Jegou B, Trainor PA, Resh MD, Antonarakis SE, Nef S: Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46, XY disorder of sex development by impeding hedgehog protein palmitoylation and signaling