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Blood glutathione concentration was quantified before and after administration of each treatment, as described in detail below

As anticipated, our findings show that most natural flavonoids activate antioxidant systems, primarily by modulating the Nrf2/GPX4 axis, with some also affecting ferritin or reducing iron accumulation in neurons, thereby further promoting the inhibition of ferroptosis

siRNA is a double-stranded RNA molecule that recognizes HBV transcripts to trigger RNA-induced silencing complex and Argonaute 2 mediated viral RNA degradation and translation repression

This breakthrough has fundamentally transformed the therapeutic landscape for KRAS-driven malignancies 8

In contrast, compared to the control group, tumors treated with Palbociclib or Telaglenastat alone did not present any changes in the levels of these markers