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Hyperglycemic-induced dysfunction of the polyol pathway is thought to induce DR in rats and humans [67, 68]

Melatonin possesses immunomodulatory properties (85) that use circadian regulation to stimulate cytokine production and lymphocyte proliferation and enhance phagocytosis (8590)

L., Monstrey, S., Motmans, J., Nahata, L.,

Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease

The monothiol mechanism for the reduction of non-glutathione disulfides is controversial and at least three different nonexclusive mechanisms have been discussed to date (Fig