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In treated tendons, researchers observe formation of granulation tissue with active angiogenesis, increased reticulin fiber production, and organized collagen formation

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In the United States, iodine status has remained generally adequate in since the 1940s although studies have shown that urinary iodine levels dropped by about half between the early 1970s and the early 1990s, and most recently mild iodine deficiency has re-emerged in pregnant women