After washing (3) in 0.01 M PBS (pH 7.2), the slides were incubated with secondary antibody (horse anti-mouse/rabbit IgG) for 30 min at 37C
Deep vein thrombosis and pulmonary thromboembolism Deep venous thrombosis (DVT) and pulmonary thromboembolism (PTE) exist on the spectrum of venous thromboembolic disease (VTE) (117)
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For example, mitochondrial dysfunction destabilizes lysosomes, amplifying oxidative stress ( 2.2.2 Endoplasmic reticulum: regulator of lipid metabolism and redox homeostasis The ER maintains cellular homeostasis through protein synthesis, lipid metabolism, and calcium storage ( - localized to the ER membranemediates cystine import for GSH synthesis ( 2.2.3 Lysosomes: controllers of iron homeostasis Lysosomes regulate cellular debris degradation, biomolecule recycling, and iron metabolismall of which influence ferroptosis ( 2.2.4 Lipid droplets: sources of polyunsaturated fatty acids Lipid droplets (LDs) are dynamic organelles serving as storage reservoirs for neutral lipids, playing pivotal roles in cellular energy homeostasis and lipid metabolism ( 2.2.5 Peroxisomes: modulators of lipid oxidation and antioxidant defense Peroxisomes regulate lipid metabolism and ROS detoxification, influencing ferroptosis ( 2.2.6 Golgi apparatus: regulatory mechanisms in ferroptosis The Golgi apparatus is a vital organelle involved in the post-translational modification, sorting, and trafficking of proteins and lipids within the cell ( Collectively, the dysfunction of key organellesincluding mitochondria, endoplasmic reticulum, lysosomes, lipid droplets, peroxisomes, and the Golgi apparatussynergistically amplifies ferroptosis susceptibility in COPD
doi: 10.1038/s41551-024-01209-3 248 YooGSAhnWGKimSYKangWChoiCParkHC
