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In addition, this growth factor directly affects neuronal cells, and dysregulation of its expression has been implicated in several neurodegenerative diseases [172]

Levine, M., Rumsey, S

Impact of NAD+ metabolism on ovarian aging

One possible interpretation is that p53 may act as a monitor of the intracellular copper concentration, on the one hand, to maintain a proper physiological copper level by preventing accumulation of excessive labile copper, and on the other hand, to eliminate copper-damaged cells when the uptake or level of copper is pathologically or experimentally upregulated

The MCC-Spain study enrolled 351 cases of stomach cancer and 3629 population-based controls between 2008 and 2013 and assessed consumption of aspartame-containing products as low- or no-calorie soft drinks and tabletop sweeteners other than saccharin (Palomar-Cros et al., 2023)