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Furthermore, the paper emphasized that GAs pharmacological actions involved multiple key signaling pathways, such as PI3K/Akt, AMPK/Sirt1/PGC1, ERK/CypD/NOX4/Poldip2, PKC/p38MAPK, Akt/GSK3, PI3K-Akt-ERK1/2, and AMPK-eNOS-FAS

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It has shown a strong safety profile in animal research and good tolerance in human research subjects, but large-scale human clinical trials are still needed

The cells were then treated with 100 g ml 1 FAC for 48 h and cultured for a further 24 h in fresh medium

Cells with normal OxPhos function cannot survive for very long in cyanide or in hypoxia