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In contrast, another estrogen deprived cell line, MCF-7:2A, appears to have elevated levels of glutathione (GSH) and is resistant to estradiol-induced apoptosis

This protective effect may be due to the fact that lung tissue produces more itaconate at 10C (100, 101, 103)

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Clinical trials of drugs targeting amino acid metabolism This review synthesizes evidence underscoring a paradigm shift in our understanding of amino acids, recasting them from passive nutrients to active governors of the hepatic microenvironment