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Humans with the ALDH2*2 gene variants are more susceptible to alcohol-induced HCC [325] and esophageal cancers [73, 326]

Gene Transcription Regulation: Within the nucleus, the Smad complex acts as a transcription factor, modulating the expression of target genes

Activation of multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), and bile acids (BAs), influences retinal physiology