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Additionally, NLRP3, P2X7R, IL-1, and interleukin-1 type 1 receptor (IL-1R1) have been implicated as being contributing factors in animal models of neurodevelopmental disorders [50,51,52], manic behavior [53], stress-sensitization, depression, and anxiety [54,55,56,57,58,59,60,61,62,63]

98,99 Then, the hydrophobic C-terminal of AMP may insert into the hydrophobic region of the cell membrane, which may change the conformation of the cell membrane and reduce the activity of P-gp by inhibiting the efflux of chemotherapy drugs, increasing the intracellular drug concentration, and reversing drug resistance of MDR tumor cells