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found that LDHA expression was significantly elevated in HCC cell line (HCCLM3 cell), correlating with advanced tumor stage and poor patient prognosis

doi: 10.1093/nar/30.1.207 Summary Keywords trained immunity, innate immune memory, monophosphoryl lipid A (MPLA), reactive oxygen species (ROS), NADPH oxidase (NOX), NADPH, xanthine oxidase (XO) Citation Hao D, Klein BD, McBride MA, Bohannon JK, Patil NK, Davis XD, Oliver MA, Dye MLN, Weidenbach S, Young JD and Sherwood ER (2026) Monophosphoryl lipid A boosts macrophage antimicrobial immunity by metabolically regulating source-specific ROS generation

Still, SA complements the ateds1 mutant phenotype, highlighting that SA and JA are not interchangeable in this context

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