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Despite these biochemical benefits, clinical outcomes of selenium supplementation remain variable, influenced by factors such as baseline selenium status, formulation, dosing strategies, timing of intervention, and patient heterogeneity

Two main mechanisms are considered responsible for injury, hypersensitivity and metabolic aberration

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Glutaminase catalyzes the conversion of glutamine to glutamate and ammonia, followed by the conversion of glutamate to alpha-ketoglutarate by either glutamate dehydrogenase or transaminase

Disturbance of sleeping cycle: High doses of glutathione may result in irregular sleep and restlessness