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Concentrations of 1,8-diMQ and 5-amino-1MQ ranging from 10 nM to 200 or 600 M, respectively, did not inhibit DNMT1 or PRMT3 (Figures 4A and 4B)

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However, its important to note that 24 weeks, while substantial for clinical trials, represents a relatively limited timeframe for assessing lifetime exposure safety