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Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk

doi:10.4172/2329-8847.1000166

"Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications." Current Neuropharmacology

The consensus is that GHK-Cu can enhance results, but it usually complements other therapies (like vitamin supplementation, topical agents, or healthy lifestyle) rather than serving as a standalone fix

Sikiric P, Jelovac N, Gjeldum A, et al