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In other words, in astrocytes

Smoking: Environmental toxins in smoke create a high demand for antioxidant protection

6c, d) [44]

Therapeutics are limited because of radioresistance, chemoresistance, and postoperative recurrence

But erastins pharmacological efficacy is constrained by its poor bioavailability and solubility, whereas the application of its two derivatives, piperazine erastin and imidazole ketone erastin (IKE), may improve its pharmacological activity [38, 39]