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However, WADA has clarified that a specific class of diuretics called Carbonic Anhydrase Inhibitors, such as dorzolamide or brinzolamine, used in the eye in conjunction with a threshold substance does not require a TUE

However, CJC-1295 (especially the DAC version) can cause sustained elevation in IGF-1, whichif mismanagedmay increase the risk of: Insulin resistance Carpal tunnel syndrome Soft tissue growth (in rare, prolonged cases) Pituitary overstimulation That said, these issues are more often associated with excessive dosing or continuous high-frequency use

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