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This result may therefore be subject to selection bias and overfitting

Int J Mol Sci 23:4259

They have been known to trigger attacks in sensitive individuals (WebMD)

Veryard L, Jones E, Weaving G, Smith E, Cheek L, Wickramasinghe A, Tabet N (2013) Pro-inflammatory cytokines IL-1 and TNF- are not associated with plasma homocysteine concentration in Alzheimers disease