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Abstract Intervertebral disc degeneration (IDD) is a significant public health issue, commonly associated with symptoms such as low back pain (LBP), and poses a substantial burden on both society and affected families

5.2 Specific regulation of the ferroptosis pathway by intestinal metabolites Ferroptosis is driven by an iron metabolism imbalance and antioxidant system collapse, with immune cells exhibiting high heterogeneity in the response process

Figure 14 The realization of abscopal effects relies on robust systemic immunity, and the formation of tertiary lymphoid structures (TLS) is key to establishing long-lasting, high-efficiency antitumor immunity

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However, oligodendrocyte death was not prevented in mice lacking FAS in oligodendrocytes revealing that FAS is also not essential for the induction of apoptosis in the cuprizone model (Hesse et al., 2010)