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Multiple mutations were present in more aggressive phenotypes with a synergistic effect

Relative mRNA expression from four technical repeats was determined using the Ct method (primer sequences for PSPH, F: TGTCAGAAATGACACGGCGA and R: GGGGGTTGCTCTGCTATGAG, RPL13A, F: CGAGGTTGGCTGGAAGTACC and R: CTTCTCGGCCTGTTTCCGTAG)

G6PD-deficient endothelial cells show reduced expression of endothelial NO synthase and decreased NO levels along with a reduction in GSH [11]

Dark spots are usually not serious

If palpitations concern you, discuss a modified titration schedule with your prescriber extending each dose step from 4 weeks to 6 weeks reduces symptom intensity without compromising long-term efficacy