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While there is a link of Hcy with neurodegeneration (Bonetti et al

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aegypti , including two substitutions at the same nucleotide position (F1534C) that have evolved and spread independently

Whilst 510% of patients taking VPA may develop a transient alanine transaminase rise, numerous cases of acute liver injury presenting with jaundice and progression to fatal liver failure have been reported, with most cases occurring within the first 6 months of treatment