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Tetrahedral DNA nanostructures (TDNs) as carriers loaded with antioxidant EGCG can efficiently penetrate the biological barrier, sustained release of drugs and antioxidant effects, and significantly improve the noise-induced hearing loss, which provides a novel delivery system for the treatment of inner ear diseases ( Different types of polyphenols may have different mechanisms in preventing cisplatin ototoxicity, and may act synergistically in enhancing its anticancer activity to reduce side effects.EGCG has antioxidant, anti-inflammatory, and inhibitory effects on Caspase-1 and NF-B, and curcumin regulates the Bcl-2/BAX ratio, inhibits the mitochondrial apoptotic pathway, and reduces Caspase-3 activation

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Intrabiliary glutathione hydrolysis - a source of glutamate in bile

The activity of glutathione-S-transferase in testicles was also measured

Briefly, cells were sequentially treated with the medium containing 25 M of CldU (Sigma-Aldrich, C6891) and then 250 M of IdU (Sigma-Aldrich, I7125) for 20 min