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Over the following years, collaborating with chemist Frank Momany, the team optimized the peptide chain structure through conformational studies, focusing on adjusting the position and stereochemistry of tryptophan residues to gradually enhance compound activity

[32] However, in more complex situations, such as nerves being damaged by severe B12 deficiency, full recovery can sometimes take up to a year

The distinct covalent bond between the glutamate and the cysteine protects GSH against protease activity

[PubMed: 12153607] 505