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Botox contains botulinum toxin

Conditions, such as diabetes or hyperglycemia, can lead to increased microglial reactivity, marked by upregulation of various molecules and pathways associated with glucose transport and sensing and inflammation and oxidative stress (Hsieh et al., 2019

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This finding suggests that primary afferent hyperexcitability is a critical pathophysiological driver of pain, and we need to both understand its basis and develop therapeutics to target it