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Specific subgroup analyses revealed that high PHD adherence reduced the risk of cerebrovascular events by 21% (HR = 0.83, 95% CI: 0.740.94) [14,16,19,21,29], the risk of heart disease by 21% (HR = 0.81, 95% CI: 0.740.88) [13,14,16,19,20,22,29], and the risk of vascular disease by 17% (HR = 0.83, 95% CI: 0.76 0.91) [17,18]

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In a casecontrol study [68], the authors assessed 102 pediatric patients with chemotherapy-induced hepatotoxicity