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The balance between the pro-oxidant and antioxidant properties of UA depends on various factors, including the pH of the environment, the presence of other pro- or antioxidant molecules, location (extracellular vs

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We think this could lead to new interventions, such as reducing the glutathione overload through synthesis inhibitors or compounds that can dissipate it. The findings also have implications for potential therapies for lung cancers related to mutations in the KEAP1 gene

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The final product of this enzymatic cascade is SFN-N-acetylcysteine, also known as a mercapturic acid