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Non-healing wounds may sometimes indicate: Diabetes or insulin resistance Poor circulation Infection Nutritional deficiencies Autoimmune conditions Vascular disease Pressure injuries Other serious medical concerns These conditions require comprehensive medical evaluation

A recent study on the effects of the SSRI paroxetine on salivary cortisol in major depressive disorder reported a "robust CAR increase especially when patients became remitters versus no change in non-remitters during paroxetine treatment" so CAR may additionally be used to assess clinical response to antidepressant therapy

van der Lugt, C

Street et al., 2018)

Not a door closing, but a dim room she has always lived in