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One double-blind, placebo-controlled RCT by investigated the use of ALC for the treatment of established CIPN (grade 2 or 3, NCI-CTC v3.0) in 240 patients with various solid tumours

Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress

Palmitic acid treatment increases intracellular DAG and subsequently induces PKC-dependent Ser153 phosphorylation of Raf-kinase inhibitor protein (RKIP) that results in RKIP-Raf1 dissociation and activation of ERK signaling pathway [165]

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The resulting oxidative stress impairs mitochondrial respiration, compromises ETC function, and increases membrane permeability, resulting in reduced ATP production and potential mitochondrial shutdown [97, 98]