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Wrbel M

As a result, creating CAR-T cells suitable for GBM treatment remains a challenge 109

The MELK inhibitor OTSSP167 protects intestinal epithelial cells by maintaining a normal composition of gut microbiota and balancing gut microbiota distribution, inhibiting ferroptosis, reducing the expression of pro-inflammatory factors in intestinal tissues, and suppressing the AKT/IKK/P65 and ERK/IKK/P65 signaling cascades in vitro and in vivo, thereby exerting a protective effect on the intestinal tissues of colitis mice [291, 292]

Importantly, pharmacological modulation of NRF2 has emerged as a promising therapeutic strategy

[Google Scholar] 9.Lillig C.H., Berndt C