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It should be taken preferably after meals to avoid stomach upset

Comparison of dorzolamide and acetazolamide as suppressors of aqueous humor flow in humans

Chronic oxidative stress and inflammation mediate the activation of multiple different downstream signaling pathways such as the NF-B, AP-1 and mammalian target of rapamycin (mTOR), Ras, and Wnt pathways, which are implicated in the development of major GI disorders such as gastric ulcer, ulcerative colitis, gastric cancer, and colorectal cancer [13,14,15,16]

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The enzyme activity of GDH in hepatocytes is 4.5 times that of other tissues