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To correct for section artifacts, we do not show the subchondral bone plate surface area per se, but express the subchondral bone plate thickness as a ratio of the subchondral bone plate area to the subchondral bone area

The mechanism of IL-4 inhibition is thought to inhibit the binding of NF-B and transcription factor Sp-1 with binding sites of the IL-4 promoter region (Mabalirajan et al., 2009)

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If regulatory submissions proceed as expected, the earliest plausible timeline for a market authorisation decision in the UK or Europe would be 2026 or 2027 though this is subject to the pace of regulatory review, the completeness of the submission package, and any additional data requests from the MHRA or EMA