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While naturally produced in the liver, levels can decline with age, stress, and poor nutrition making supplementation beneficial for overall wellness

A further limitation is that current Gut-on-a-Chip platforms are primarily optimized for PK interrogation rather than comprehensive PD assessment unless the pharmacological target resides within intestinal tissue

If BPC-157's tissue-protective properties translate to humans, the compounds could theoretically be deeply synergistic: one driving fat loss, the other protecting the musculoskeletal architecture during the process

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doi: 10.1016/j.tim.2021.04.010 24 FlyerDCRamakrishnaVMillerCMyersHMcDanielMRootKet al