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p53-specific responses were observed in 0%, 20%, and 41.7% of SCLC patients in arm A (observation), B (Ad.p53-DC), and C (Ad.p53-DC plus ATRA), respectively (124)

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While the reaction between GSH and the hydroxyl radical is very fast, this powerful oxidant also reacts rapidly with numerous other metabolites that are present in the cellular environment at higher concentrations than GSH, such as ascorbate and sugars (Table 1)

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