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doi: 10.1634/theoncologist.2019-0835 86 de GramontAVan CutsemE

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Type I collagen is synthesized and secreted by fibroblasts, using the exocytic pathway that is employed for other secretory proteins (see Chapter 21), but the biosynthesis of collagen is noteworthy for the extensive number of processing steps required to prepare the protein for assembly in the extracellular matrix

Unlike pharmaceutical sleep aids that cause next-day drowsiness, cognitive impairment, tolerance, and dependency, DSIP enhances sleep quality without sedative side effects, maintains normal sleep architecture, causes no morning grogginess, develops no tolerance requiring dose escalation, and demonstrates no withdrawal symptoms or addiction potential