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In addition to antihypertensive activity, tripeptides such as GHK-Cu have been reported to contribute to vascular repair following injury

In one investigation, GHK-Cu was speculated to upregulate tight junction proteins ZO-1 and occludin in a co-culture model of epithelial-macrophage interaction (via the SIRT1/STAT3 pathway), thereby supporting tissue-barrier integrity in inflamed mucosa

Topical GHK-CU primarily affects the skin directly

Once the biological processes activate, they sustain themselves

The sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Or in single-letter amino acid code: GEPPPGKPADDAGLV This specific arrangement was selected from the larger gastric BPC protein based on its superior stability and biological activity