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Absorption and Distribution 11.2.1

Crossing the Blood-Brain Barrier by Alex Richardson Due to the complex nature of the central nervous system (CNS), the effects of drugs in the brain can be adverse and unpredictable

Not surprisingly, PEGylation has emerged as the gold standard for engineering muco-penetrating LNPs for stability 161,162

marneffei , including glutathione biosynthetic enzymes (Gcs1 and Gcs2), glutathione peroxidase (Gpx1), glutathione reductase (Glr1), and a family of glutathione S-transferase (Gst)

The entire right brain hemisphere was immersed in 4% paraformaldehyde (PFA) made in PBS, 0.1 m, pH 7.4, for 48 h, divided transversally into four tissue slabs, according to a pig brain stereotaxic atlas (Flix et al., 1999), and fixed for an additional 6 h in PFA